Description

n-[2,3,5,6-Tetradeuterio-4-[(4-Nitrophenyl)Sulfamoyl]Phenyl]Acetamide is a deuterated derivative of the pharmaceutical intermediate N-[4-[(4-Nitrophenyl)Sulfamoyl]Phenyl]Acetamide. This compound matters for its utility as a stable isotope-labeled internal standard in quantitative mass spectrometry, providing enhanced accuracy and reliability in analytical measurements. It is primarily needed by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and quality control of complex chemical syntheses.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of its non-deuterated counterpart in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Pharmaceutical Impurity Profiling: Used in method development and validation to identify and quantify related substances and degradation products in active pharmaceutical ingredients (APIs).
• Bioanalytical Assay Development: Provides a stable isotope-labeled spike for creating calibration curves and ensuring method robustness and reproducibility.
• Metabolomics Research: Facilitates the accurate measurement of specific metabolites or pathway intermediates in complex biological systems.
• Chemical Synthesis Monitoring: Acts as a tracer or reference material to monitor reaction yields and purity during the synthesis of sulfonamide-based compounds.

Basic Information

Product Name	n-[2,3,5,6-Tetradeuterio-4-[(4-Nitrophenyl)Sulfamoyl]Phenyl]Acetamide
CAS No.	1794753-46-0
Molecular Formula	C14H9D4N3O5S
Molecular Weight	335.36 g/mol
Synonyms	N-[4-[(4-Nitrophenyl)sulfamoyl]phenyl]acetamide-d4; 4'-Acetamidophenyl-4-nitrophenyl Sulfone-d4; Deuterated N-Acetyl Sulfanilamide Nitrophenyl Derivative; 4-Acetamidobenzenesulfonamide, N-(4-nitrophenyl)-, tetradeuterated; Tetradeuterated N-[4-[(4-Nitrophenyl)sulfamoyl]phenyl]acetamide; Stable Isotope Labeled Sulfonamide Intermediate; d4-N-[4-[(4-Nitrophenyl)Sulfamoyl]Phenyl]Acetamide
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality protocols to ensure isotopic purity and chemical integrity, which are critical for analytical applications. Each batch undergoes comprehensive analysis, including NMR (¹H and ²H) for isotopic enrichment verification and HPLC/MS for chemical purity and identity confirmation. Certificates of Analysis (COA) detailing isotopic purity (e.g., D ≥ 98%), chemical purity (typically ≥95% by HPLC), and analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C to maximize stability.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (²H NMR)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.