Description

4-(Chloromethyl)-2,5-Oxazolidinedione-D3 is a deuterated isotopologue of a key oxazolidinedione derivative, serving as a crucial building block in advanced organic synthesis. This compound is specifically valued for its role in the preparation of isotopically labeled active pharmaceutical ingredients (APIs) and metabolites for pharmacokinetic and metabolic studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, development, and analytical method validation, where the use of deuterated standards enhances the precision of mass spectrometry and NMR analyses.

Application

• Deuterated Standard for Analytical Chemistry: Used as an internal standard in LC-MS and GC-MS for the quantitative analysis of pharmaceuticals and their metabolites.
• Pharmaceutical Intermediate: A key synthon in the synthesis of deuterium-labeled drug candidates, particularly in neurological and anti-infective research.
• Metabolite Synthesis: Employed in the preparation of stable isotope-labeled metabolites for drug metabolism and pharmacokinetics (DMPK) studies.
• Mechanistic Studies: Facilitates reaction pathway elucidation and isotope effect studies in medicinal chemistry.
• Reference Material: Serves as a high-purity certified reference material (CRM) for quality control and regulatory compliance in API manufacturing.

Basic Information

Item	Details
Product Name	4-(Chloromethyl)-2,5-Oxazolidinedione-D3
CAS No.	1794713-40-8
Molecular Formula	C4H2D3ClNO3
Molecular Weight	152.56 g/mol (approx.)
Synonyms	4-(Chloromethyl)-2,5-oxazolidinedione-d3; 2,5-Oxazolidinedione, 4-(chloromethyl)-, 3,3,5-d3; Deuterated 4-Chloromethyl-2,5-oxazolidinedione; (3,3,5-d3)-4-(Chloromethyl)-2,5-oxazolidinedione; 4-(Chloromethyl)-1,3-oxazolidine-2,5-dione-d3; Isotopically labeled oxazolidinedione derivative; Chloromethyl-oxazolidinedione-d3; Deuterium labeled API intermediate
EINECS	Contact for details

Quality Control

Our 4-(Chloromethyl)-2,5-Oxazolidinedione-D3 is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by NMR/MS), and identity confirmation. We adhere to cGMP principles where applicable to support our clients in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.