Description

[2-Amino-5-(Trifluoromethyl)Phenyl]Boronic Acid is a specialized aromatic boronic acid derivative featuring both an amino group and a trifluoromethyl substituent. This unique bifunctional structure makes it a highly valuable building block in modern synthetic chemistry, particularly for Suzuki-Miyaura cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require the precise introduction of complex aryl fragments to create novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct advanced herbicide and fungicide molecules, leveraging the metabolic stability imparted by the trifluoromethyl group.
• Material Science Research: Serves as a monomer or linker for creating novel organic frameworks, polymers, and liquid crystals with specific electronic properties.
• Suzuki-Miyaura Cross-Coupling: Acts as a versatile boronic acid partner for palladium-catalyzed C-C bond formation to create biaryl structures under mild conditions.
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors due to its ability to form reversible complexes with diols and other functional groups.
• Catalyst Ligand Development: The amino group allows for further functionalization to create novel bidentate ligands for transition metal catalysis.

Basic Information

Product Name	[2-Amino-5-(Trifluoromethyl)Phenyl]Boronic Acid
CAS No.	1793091-29-8
Molecular Formula	C7H7BF3NO2
Molecular Weight	204.95 g/mol
Synonyms	2-Amino-5-(trifluoromethyl)benzeneboronic acid; (2-Amino-5-(trifluoromethyl)phenyl)boronic acid; Boronic acid, B-[2-amino-5-(trifluoromethyl)phenyl]-; 5-(Trifluoromethyl)-2-aminophenylboronic acid; 2-Amino-alpha,alpha,α-trifluoro-m-tolylboronic acid; 2-Amino-5-trifluoromethylphenylboronic Acid; m-Amino-alpha,alpha,α-trifluorophenylboronic Acid
EINECS	Contact for details

Quality Control

Our [2-Amino-5-(Trifluoromethyl)Phenyl]Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.