Description

2-Desbutylcarboxy-2-(n-Hydroxyheptanamino) Bendamustine is a key pharmaceutical intermediate and derivative of the established chemotherapeutic agent bendamustine. This compound is of significant interest for research and development in novel oncology treatments, particularly in the synthesis of targeted prodrugs and antibody-drug conjugates (ADCs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers specializing in high-potency active pharmaceutical ingredients (HPAPIs) for cancer therapy.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of next-generation bendamustine analogs and prodrugs.
• Antibody-Drug Conjugate (ADC) Payload Research: Serves as a potent cytotoxic warhead for conjugation to monoclonal antibodies in targeted cancer therapy development.
• Oncology Drug Discovery: Used in preclinical studies to investigate new mechanisms of action and improve therapeutic indices for hematologic and solid tumors.
• Chemical Biology Studies: Employed as a tool compound to study DNA alkylation mechanisms and cellular apoptosis pathways.
• Process Chemistry & Scale-Up: Sourced by manufacturers for process development and optimization leading to commercial-scale API production.

Basic Information

Product Name	2-Desbutylcarboxy-2-(n-Hydroxyheptanamino) Bendamustine
CAS No.	1793059-58-1
Molecular Formula	C21H30Cl2N3O4
Molecular Weight	459.39 g/mol
Synonyms	2-Desbutylcarboxy-2-(n-Hydroxyheptanamino) Bendamustine; 2-Desbutylcarboxy-2-(7-Hydroxyheptylamino) Bendamustine; Bendamustine Hydroxyheptylamino Derivative; 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl-2-[[(7-hydroxyheptyl)amino]methyl]-; 1793059-58-1; Bendamustine Impurity; Bendamustine Related Compound
EINECS	Contact for details

Quality Control

Our 2-Desbutylcarboxy-2-(n-Hydroxyheptanamino) Bendamustine is manufactured under strict quality systems suitable for pharmaceutical research. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.