Description

6-o-Des(6-Amino-α-D-Gluocopyranosyl) Amikacin is a key chemical intermediate and reference standard derived from the semisynthetic aminoglycoside antibiotic, amikacin. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis and analytical characterization of novel antibiotic derivatives. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in the development of anti-infective agents, method validation, and quality control processes.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthetic pathways for novel aminoglycoside antibiotics and derivatives.
• Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control (QC/QA) of amikacin and related substances in pharmaceutical products.
• Metabolite Studies: Employed in pharmacokinetic and metabolic research to study the breakdown pathways of amikacin.
• Impurity Profiling: Essential for identifying, quantifying, and monitoring specified and unspecified impurities in amikacin active pharmaceutical ingredient (API) batches.
• Biochemical Research: Used in studies investigating the structure-activity relationships (SAR) and mechanisms of action of aminoglycoside antibiotics.

Basic Information

Product Name	6-o-Des(6-Amino-α-D-Gluocopyranosyl) Amikacin
CAS No.	1793053-92-5
Molecular Formula	C22H43N5O12
Molecular Weight	569.61 g/mol
Synonyms	6'-Deoxy-6'-aminoamikacin; 6'-Deaminoamikacin; 6'-N-Deaminoamikacin; Amikacin 6'-Deamino Derivative; 1-N-[(S)-4-Amino-2-hydroxybutyryl]-6'-deamino-6'-deoxykanamycin A; 6'-Deamino-6'-deoxyamikacin; 6'-Deaminoamikacin Sulfate (salt form); 6-o-Des(6-amino-α-D-glucopyranosyl)amikacin
EINECS	Contact for details

Quality Control

Our 6-o-Des(6-Amino-α-D-Gluocopyranosyl) Amikacin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the stringent requirements for use as a pharmaceutical intermediate and reference standard. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.