Description

4-(1-Cyano-1-Methylethyl)-2-Fluorophenylboronic Acid is a high-value, multi-functional boronic acid derivative used as a critical building block in advanced organic synthesis. Its core value lies in enabling the precise construction of complex molecules through robust cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in materials science for creating specialized polymers and electronic materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in modern herbicides, fungicides, and insecticides, contributing to improved efficacy and selectivity.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for forming carbon-carbon bonds between aromatic rings, a fundamental reaction in medicinal and process chemistry.
• Materials Science Research: Employed in the development of organic light-emitting diodes (OLEDs), liquid crystals, and other advanced organic electronic materials due to its functionalized aromatic structure.
• Chemical Biology & Probe Development: Useful for creating molecular probes and bioconjugates that leverage the boronic acid group's affinity for diols, aiding in sensor and diagnostic tool development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, high-purity boronic acid derivatives.

Basic Information

Product Name	4-(1-Cyano-1-Methylethyl)-2-Fluorophenylboronic Acid
CAS No.	1793003-65-2
Molecular Formula	C10H11BFNO2
Molecular Weight	207.01 g/mol
Synonyms	2-Fluoro-4-(2-cyano-2-propyl)phenylboronic Acid; 4-(2-Cyano-2-propyl)-2-fluorobenzeneboronic Acid; (4-(1-Cyano-1-methylethyl)-2-fluorophenyl)boronic Acid; 4-(1-Cyano-1-methylethyl)-2-fluorobenzeneboronic Acid; B-[4-(1-Cyano-1-methylethyl)-2-fluorophenyl]boronic Acid; 2-Fluoro-4-(α-cyanoisopropyl)phenylboronic Acid
EINECS	Contact for details

Quality Control

Our 4-(1-Cyano-1-Methylethyl)-2-Fluorophenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, impurity profile, and residual solvent content. Our quality system is designed to support cGMP (current Good Manufacturing Practice) compliance for pharmaceutical intermediate use, and we can accommodate specific customer testing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.