Description

(S)-tert-Butyl 3-(2-Hydroxypropan-2-Yl)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and Boc-protected pyrrolidine derivative of significant importance in modern synthetic chemistry. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, enabling precise control over the three-dimensional architecture of target compounds. This intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and novel bioactive compounds. The CAS number for this compound is 1788041-39-3.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Research: Used in the development of enantiomerically pure pesticides and herbicides where specific stereochemistry is crucial for bioactivity.
• Asymmetric Synthesis: Serves as a versatile precursor for constructing complex natural products and other stereochemically demanding molecules.
• Ligand and Catalyst Development: The pyrrolidine core can be functionalized to create novel chiral ligands for asymmetric catalysis.
• Peptidomimetics: The Boc-protected amine and hydroxyl groups make it a valuable building block for designing peptide mimics with enhanced stability.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study enzyme function and biological pathways.

Basic Information

Item	Details
Product Name	(S)-tert-Butyl 3-(2-Hydroxypropan-2-Yl)Pyrrolidine-1-Carboxylate
CAS No.	1788041-39-3
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	(3S)-1-(tert-Butoxycarbonyl)-3-(2-hydroxypropan-2-yl)pyrrolidine; (S)-1-Boc-3-(2-hydroxy-2-propyl)pyrrolidine; (S)-tert-Butyl 3-(2-hydroxy-2-propyl)pyrrolidine-1-carboxylate; (S)-1-N-Boc-3-(2-hydroxyisopropyl)pyrrolidine; (S)-3-(2-Hydroxypropan-2-yl)-1-(tert-butoxycarbonyl)pyrrolidine; Boc-(S)-3-(2-Hydroxyisopropyl)pyrrolidine; (S)-3-(1-Hydroxy-1-methylethyl)-1-(tert-butoxycarbonyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 3-(2-Hydroxypropan-2-Yl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for advanced pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and residual solvent levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.