Description

4-Cyclopropyl-2-Fluoro-n-[5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl] is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group, which is critical for modern cross-coupling reactions. This compound is essential for the efficient synthesis of complex molecules, enabling the rapid construction of carbon-carbon bonds under mild conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron-containing coupling partner for the synthesis of biaryl and heterobiaryl structures in drug discovery.
• Pharmaceutical Intermediate: Used in the research and development of potential therapeutic agents, particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Employed in the creation of advanced fungicides and herbicides with novel modes of action.
• Material Science Research: Acts as a building block for organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Can be used to create chemical probes for studying protein function and enzyme activity.
• Process Chemistry & Scale-Up: Provides a reliable and stable boronate source for optimizing and scaling manufacturing routes for target molecules.

Basic Information

Product Name	4-Cyclopropyl-2-Fluoro-n-[5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]
CAS No.	1787294-47-6
Molecular Formula	C20H24B F2N O2
Molecular Weight	359.22 g/mol
Synonyms	2-Fluoro-4-cyclopropyl-N-[5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]benzamide; 4-Cyclopropyl-2-fluoro-N-[5-fluoro-2-methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]benzamide; 1787294-47-6; Benzamide, 2-fluoro-4-cyclopropyl-N-[5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; Boronic acid, B-[3-[(2-fluoro-4-cyclopropylbenzoyl)amino]-4-fluoro-6-methylphenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our production of 4-Cyclopropyl-2-Fluoro-n-[5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl] adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with client specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.