Description

Benzene, 1-Bromo-4-(1-Fluorocyclopropyl)- is a high-value halogenated aromatic building block featuring a unique fluorinated cyclopropyl substituent. This compound is critical for advanced organic synthesis, enabling the introduction of both bromo and fluoroalkyl functional groups in a single, strategically positioned molecule. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorocyclopropyl moiety can enhance biological activity and metabolic stability.
• Material Science: Acts as a monomer or functionalization agent in the production of specialty polymers and liquid crystals with tailored electronic or optical properties.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Fluorine Chemistry Library Synthesis: A valuable building block for constructing diverse compound libraries in fluorine-focused drug discovery, leveraging the unique properties of the fluorine atom.

Basic Information

Product Name	Benzene, 1-Bromo-4-(1-Fluorocyclopropyl)-
CAS No.	1783975-92-7
Molecular Formula	C9H8BrF
Molecular Weight	215.06 g/mol
Synonyms	1-Bromo-4-(1-fluorocyclopropyl)benzene; 4-Bromo-1-(1-fluorocyclopropyl)benzene; p-Bromo(1-fluorocyclopropyl)benzene; (1-Fluorocyclopropyl)-4-bromobenzene; 1-Fluorocyclopropyl-4-bromobenzene; 4-Bromophenyl-1-fluorocyclopropane
EINECS	Contact for details

Quality Control

Every batch of Benzene, 1-Bromo-4-(1-Fluorocyclopropyl)- is produced and analyzed under strict quality management protocols. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including GC, HPLC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.