Description

1-Bromo-4-Fluoro-2-Methoxy-3-Methylbenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecular architectures with precise regiochemistry. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the bromo and fluoro substituents enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the rapid diversification of chemical space in medicinal chemistry libraries.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution on aromatic systems and for developing new fluorination methodologies.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects requiring high-fidelity, multi-halogenated benzene derivatives.

Basic Information

Product Name	1-Bromo-4-Fluoro-2-Methoxy-3-Methylbenzene
CAS No.	1783385-83-0
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	4-Bromo-1-fluoro-2-methoxy-3-methylbenzene; 3-Methyl-2-methoxy-4-bromofluorobenzene; 2-Bromo-5-fluoro-6-methoxytoluene; 1-Bromo-4-fluoro-2-methoxy-3-methyl-benzene; 4-Fluoro-2-methoxy-3-methylbromobenzene; 3-Methyl-4-bromo-1-fluoro-2-methoxybenzene; Benzene, 1-bromo-4-fluoro-2-methoxy-3-methyl-
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Fluoro-2-Methoxy-3-Methylbenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with global regulatory frameworks, including REACH and TSCA.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.