Description

1-(Difluoromethyl)Cyclohexane-1-Carboxylic Acid is a specialized fluorinated carboxylic acid building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluoromethyl group on a cyclohexane ring, makes it a valuable precursor for introducing lipophilic and metabolically stable motifs into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting metabolic stability and improved bioavailability.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Advanced Material Precursor: Used in the synthesis of fluorinated polymers, liquid crystals, and specialty chemicals requiring specific electronic or physical characteristics.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex, fluorinated organic molecules.
• Proteolysis Targeting Chimera (PROTAC) Linker Component: Potential use in the design of bifunctional molecules for targeted protein degradation.

Basic Information

Product Name	1-(Difluoromethyl)Cyclohexane-1-Carboxylic Acid
CAS No.	1781320-56-6
Molecular Formula	C8H12F2O2
Molecular Weight	178.18 g/mol
Synonyms	1-(Difluoromethyl)cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid, 1-(difluoromethyl)-; 1-(Difluoromethyl)-1-cyclohexanecarboxylic acid; α-(Difluoromethyl)cyclohexaneacetic acid (related); Difluoromethyl cyclohexyl carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 1-(Difluoromethyl)Cyclohexane-1-Carboxylic Acid is produced and tested under strict quality management protocols to ensure consistency and purity for research and development applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (typically 15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, handle with appropriate personal protective equipment in a fume hood or well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.