Description

2-(Fluoromethyl)Pyrrolidine Hydrochloride is a high-purity, fluorinated pyrrolidine derivative offered as a hydrochloride salt. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel active pharmaceutical ingredients (APIs). It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where the introduction of a fluoromethyl group can significantly alter the biological activity and metabolic stability of target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, especially in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the fluorine moiety enhances efficacy and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Incorporated into peptide backbones to create metabolically stable analogs for biochemical studies.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and receptor interactions.
• Material Science: A potential monomer or modifier for creating specialty polymers with unique properties.

Basic Information

Product Name	2-(Fluoromethyl)Pyrrolidine Hydrochloride
CAS No.	1781050-17-6
Molecular Formula	C5H11ClFN
Molecular Weight	139.60 g/mol
Synonyms	2-(Fluoromethyl)pyrrolidine HCl; Pyrrolidine, 2-(fluoromethyl)-, hydrochloride; 2-Fluoromethylpyrrolidine hydrochloride; (S)-2-(Fluoromethyl)pyrrolidine hydrochloride (if chiral); (R)-2-(Fluoromethyl)pyrrolidine hydrochloride (if chiral); 2-Fluoromethyl-1-azacyclopentane hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Fluoromethyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis (if applicable), and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements of our global clientele. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (if applicable)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.