Description

1-[(Benzyloxy)Carbonyl]-3-Fluoroazetidine-3-Carboxylic Acid is a high-value, fluorinated azetidine derivative that serves as a critical building block in modern synthetic chemistry. This compound is essential for medicinal chemistry research and development, enabling the precise introduction of a fluorine-substituted azetidine scaffold into target molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of fluorinated azetidine motifs in drug discovery programs, especially for protease targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the effects of fluorine and the constrained azetidine ring on potency, metabolic stability, and bioavailability.
• Peptidomimetic Synthesis: Serves as a protected, fluorinated amino acid analog for the design and synthesis of novel peptidomimetics and macrocyclic compounds.
• Chemical Biology Probes: Employed in the development of chemical probes and tool compounds to study biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and the cGMP production of advanced intermediates for clinical trial materials.

Basic Information

Product Name	1-[(Benzyloxy)Carbonyl]-3-Fluoroazetidine-3-Carboxylic Acid
CAS No.	1781046-72-7
Molecular Formula	C12H12FNO4
Molecular Weight	253.23 g/mol
Synonyms	3-Fluoro-1-[(phenylmethoxy)carbonyl]azetidine-3-carboxylic acid; 3-Fluoroazetidine-3-carboxylic acid, 1-Cbz-protected; 1-Cbz-3-fluoroazetidine-3-carboxylic acid; 1-N-Carbobenzoxy-3-fluoroazetidine-3-carboxylic acid; Z-3-Fluoroazetidine-3-carboxylic acid; (3-Fluoroazetidin-3-yl)carboxylic acid, N-Cbz protected; 1-(Benzyloxycarbonyl)-3-fluoroazetidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-[(Benzyloxy)Carbonyl]-3-Fluoroazetidine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.