Description

2,4-Difluoro-3-Nitrophenylboronic Acid is a specialized organoboron building block featuring a nitrophenyl core with strategic fluorine substitutions. This compound matters as a critical intermediate in modern synthetic chemistry, enabling the precise construction of complex molecules through cross-coupling reactions. Pharmaceutical, agrochemical, and advanced material researchers need it for developing new active ingredients and functional materials, leveraging its unique halogenated aromatic structure.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and fluorinated pharmaceutical development.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for creating functional organic materials, such as organic light-emitting diodes (OLEDs) and liquid crystals, where the nitrophenylboronic acid moiety aids in molecular assembly.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and sensors that utilize boronic acid chemistry for detecting sugars or other diol-containing biomolecules.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in organic and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	2,4-Difluoro-3-Nitrophenylboronic Acid
CAS No.	1779496-54-6
Molecular Formula	C6H4BF2NO4
Molecular Weight	202.91 g/mol
Synonyms	(2,4-Difluoro-3-nitrophenyl)boronic acid; 2,4-Difluoro-3-nitrobenzeneboronic acid; B-(2,4-Difluoro-3-nitrophenyl)boronic acid; 3-Nitro-2,4-difluorophenylboronic acid; 2,4-Difluoro-3-nitrobenzeneboronic acid pinacol ester (protected form); 2,4-Difluoro-3-nitrophenyl-B(OH)2; CAS 1779496-54-6
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Nitrophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.