Description

4-Formyl-2-(Trifluoromethyl)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl group and a trifluoromethyl substituent on the aromatic ring, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and advanced materials sectors, where it enables the synthesis of novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of biaryl compounds, which are core structures in many active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides by incorporating the trifluoromethyl group, which often enhances biological activity and metabolic stability.
• Ligand Synthesis: The formyl group allows for further functionalization to create specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where the boronic acid moiety facilitates polymerization or conjugation.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and the development of chemical probes and sensors due to its selective reactivity.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects requiring the introduction of both aldehyde and trifluoromethylphenyl functionalities.

Basic Information

Product Name	4-Formyl-2-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1777807-55-2
Molecular Formula	C8H6BF3O3
Molecular Weight	217.94 g/mol
Synonyms	[2-(Trifluoromethyl)-4-formylphenyl]boronic acid; 4-Formyl-2-(trifluoromethyl)benzeneboronic acid; 2-(Trifluoromethyl)-4-formylbenzeneboronic acid; 4-Carboxy-2-(trifluoromethyl)phenylboronic acid (tautomeric form); (4-Formyl-2-(trifluoromethyl)phenyl)boronic acid; Boronic acid, B-[4-formyl-2-(trifluoromethyl)phenyl]-; CAS 1777807-55-2
EINECS	Contact for details

Quality Control

Our 4-Formyl-2-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), identity confirmation (NMR, IR), and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC Area %)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.