Description

Boronic Acid, B-[2-Fluoro-5-Methoxy-3-(Trifluoromethyl)Phenyl]- is a high-purity, advanced pharmaceutical intermediate and building block characterized by its unique trifluoromethyl and fluoro-substituted aromatic ring system. This compound is essential for modern synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the discovery and production of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), especially in oncology, CNS, and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the fluorine and trifluoromethyl groups.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a key electrophilic partner in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and inhibitors for studying enzyme function and protein-protein interactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and custom synthesis projects.

Basic Information

Product Name	Boronic Acid, B-[2-Fluoro-5-Methoxy-3-(Trifluoromethyl)Phenyl]-
CAS No.	1772622-44-2
Molecular Formula	C9H7BF4O3
Molecular Weight	250.96 g/mol
Synonyms	(2-Fluoro-5-methoxy-3-(trifluoromethyl)phenyl)boronic acid; 2-Fluoro-5-methoxy-3-(trifluoromethyl)benzeneboronic acid; B-(2-Fluoro-5-methoxy-3-(trifluoromethyl)phenyl)boronic acid; [2-Fluoro-5-methoxy-3-(trifluoromethyl)phenyl]boronic acid; Boronic acid, B-[2-fluoro-5-methoxy-3-(trifluoromethyl)phenyl]- (9CI); 2-Fluoro-5-methoxy-3-trifluoromethylphenylboronic acid
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-[2-Fluoro-5-Methoxy-3-(Trifluoromethyl)Phenyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.