Description

1,3-Dioxolane, 2-[2-[(2R,5R)-2,5-Diethyl-1-Phospholanyl]Phenyl]- is a high-value, chiral organophosphorus ligand with a specific stereochemical configuration. This compound matters for its critical role in enabling highly selective and efficient asymmetric catalysis, a cornerstone of modern pharmaceutical and fine chemical synthesis. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise control over reaction stereochemistry to produce enantiomerically pure intermediates and active ingredients.

Application

• As a chiral ligand in asymmetric hydrogenation, hydroformylation, and other transition metal-catalyzed reactions.
• For the synthesis of enantiomerically pure pharmaceutical intermediates, such as active pharmaceutical ingredients (APIs) for cardiovascular, central nervous system, and antiviral drugs.
• In the development of advanced agrochemicals where specific stereoisomers exhibit superior biological activity.
• As a key component in catalyst screening libraries for process research and optimization in fine chemical manufacturing.
• For academic and industrial research in organometallic chemistry and new catalytic methodologies.
• In the production of specialty polymers and advanced materials requiring chiral induction.

Basic Information

Product Name	1,3-Dioxolane, 2-[2-[(2R,5R)-2,5-Diethyl-1-Phospholanyl]Phenyl]-
CAS No.	1710765-27-7
Molecular Formula	C17H25O2P
Molecular Weight	292.35 g/mol
Synonyms	(2R,5R)-2,5-Diethyl-1-[2-(1,3-dioxolan-2-yl)phenyl]phosphole; (R,R)-2,5-Diethyl-1-[2-(1,3-dioxolan-2-yl)phenyl]phospholane; Dioxolane-functionalized Chiral Phospholane Ligand; Asymmetric Hydrogenation Ligand; Chiral Bidentate Phosphorus Ligand; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our high-purity chiral ligands are produced under strict quality control protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical identity, enantiomeric excess (ee), and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.