Description

2,2-Difluoro-1-p-Tolyl-Cyclopropanecarboxylic Acid is a high-value, fluorinated cyclopropane derivative that serves as a critical synthetic intermediate. Its unique structure, featuring a difluorocyclopropane ring fused with a toluyl-substituted carboxylic acid, makes it an essential building block for introducing conformational rigidity and fluorine atoms into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorinated cyclopropane moiety can enhance biological activity and environmental stability.
• Material Science: Serves as a monomer or building block for creating specialty polymers and liquid crystals with tailored thermal and optical properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and enzyme inhibitors for biochemical and pharmacological research due to its ability to modulate protein-ligand interactions.
• Catalyst & Ligand Development: Acts as a scaffold for developing chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorine Chemistry Research: An important compound for studying the effects of gem-difluoro substitution on cyclopropane ring strain and reactivity in organic synthesis.

Basic Information

Product Name	2,2-Difluoro-1-p-Tolyl-Cyclopropanecarboxylic Acid
CAS No.	1707737-35-6
Molecular Formula	C11H10F2O2
Molecular Weight	212.19 g/mol
Synonyms	1-(4-Methylphenyl)-2,2-difluorocyclopropanecarboxylic Acid; 2,2-Difluoro-1-(4-methylphenyl)cyclopropanecarboxylic Acid; p-Tolyl-2,2-difluorocyclopropanecarboxylic Acid; 4-Methyl-α-(2,2-difluorocyclopropyl)benzenecarboxylic Acid; DFPC Acid; 1707737-35-6; 1-(p-Tolyl)-2,2-difluorocyclopropane-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-1-p-Tolyl-Cyclopropanecarboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profile. Our quality protocols are designed to support regulatory filings in pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.