Description

3-Bromo-5-(Pentafluorosulfur)Benzenesulfonylchloride is a high-value, multi-functional organosulfur building block characterized by its unique combination of bromo, pentafluorosulfur, and sulfonyl chloride reactive handles. This compound matters for its critical role in advanced organic synthesis, enabling the precise construction of complex molecules for demanding applications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries seeking to introduce sulfonamide linkages or fluorinated aromatic systems.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly sulfonamide-based drugs and fluorinated bioactive molecules.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the pentafluorosulfur and sulfonyl groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functional polymers, liquid crystals, and advanced electronic materials requiring specific fluorinated aromatic units.
• Chemical Biology Probes: Utilized in developing activity-based probes and covalent inhibitors for target identification and validation in drug discovery.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse biaryl structures.
• Sulfonamide Library Synthesis: The reactive sulfonyl chloride group is ideal for high-throughput parallel synthesis to generate diverse sulfonamide libraries for screening.

Basic Information

Product Name	3-Bromo-5-(Pentafluorosulfur)Benzenesulfonylchloride
CAS No.	1706453-16-8
Molecular Formula	C6H2BrClF5O2S2
Molecular Weight	371.56 g/mol
Synonyms	3-Bromo-5-(pentafluoro-λ6-sulfanyl)benzenesulfonyl chloride; Benzenesulfonyl chloride, 3-bromo-5-(pentafluorosulfur)-; 3-Bromo-5-(SF5)benzenesulfonyl chloride; SF5-Aromatic Sulfonyl Chloride Intermediate; (3-Bromo-5-sulfurpentafluorophenyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(Pentafluorosulfur)Benzenesulfonylchloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided to guarantee reproducible performance and supply chain traceability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.