Description

trans-2-Fluorocyclopropanecarbonitrile is a high-value, fluorinated cyclopropane building block of significant interest in advanced organic synthesis. Its unique strained-ring structure combined with fluorine and nitrile functional groups makes it a versatile precursor for creating complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the fluorocyclopropane moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis, leveraging the stereochemistry of the cyclopropane ring.
• Material Science Precursor: Potential building block for specialty polymers or liquid crystals, where the fluorine atom can modify electronic properties and solubility.
• Fluorine Chemistry Exploration: An important substrate for studying novel fluorination reactions and the stereoelectronic effects of the trans-fluorine substituent.

Basic Information

Product Name	trans-2-Fluorocyclopropanecarbonitrile
CAS No.	1706444-84-9
Molecular Formula	C4H4FN
Molecular Weight	85.08 g/mol
Synonyms	trans-2-Fluorocyclopropane-1-carbonitrile; (1R,2S)-2-Fluorocyclopropanecarbonitrile; (1S,2R)-2-Fluorocyclopropanecarbonitrile; 2-Fluorocyclopropanecarbonitrile (trans-); Fluorocyclopropanecarbonitrile; trans-2-Fluorocyclopropanecarboxitrile
EINECS	Contact for details

Quality Control

Our trans-2-Fluorocyclopropanecarbonitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.