Description

(R)-3,3'-Bis(3,5-Difluorophenyl)-[1,1'-Binapthalene]-2,2'-Diol is a high-value, enantiomerically pure chiral ligand and catalyst precursor belonging to the BINOL derivative family. This compound is critically important for facilitating highly selective asymmetric synthesis reactions, enabling the production of single-enantiomer intermediates with superior optical purity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials, where precise stereochemical control is paramount.

Application

• As a chiral ligand in asymmetric metal catalysis (e.g., with Rh, Ru, Cu) for C-C and C-X bond-forming reactions.
• As a key precursor for synthesizing more complex, tunable chiral phosphoramidite and phosphine ligands.
• In the asymmetric synthesis of pharmaceutical intermediates, particularly for central nervous system (CNS) and cardiovascular drugs.
• For enantioselective catalysis in fine chemical and agrochemical manufacturing processes.
• As a building block in materials science for creating chiral polymers or frameworks with optical properties.
• In academic and industrial R&D for method development in organic and organometallic chemistry.

Basic Information

Product Name	(R)-3,3'-Bis(3,5-Difluorophenyl)-[1,1'-Binapthalene]-2,2'-Diol
CAS No.	1706439-53-3
Molecular Formula	C32H18F4O2
Molecular Weight	510.48 g/mol
Synonyms	(R)-3,3'-Bis(3,5-difluorophenyl)-1,1'-bi-2-naphthol; (R)-3,3'-Bis(3,5-difluorophenyl)-BINOL; (R)-3,3'-Di(3,5-difluorophenyl)-BINOL; (R)-3,3'-Bis(3,5-difluorophenyl)-2,2'-dihydroxy-1,1'-binaphthyl; (R)-3,3'-(3,5-Difluorophenyl)2-BINOL; (R)-3,3'-Bis(3,5-difluorophenyl)-H8-BINOL (Note: This is incorrect for this specific structure but is a common search confusion); Chiral BINOL Derivative with 3,5-Difluorophenyl Substituents
EINECS	Contact for details

Quality Control

Our production of (R)-3,3'-Bis(3,5-Difluorophenyl)-[1,1'-Binapthalene]-2,2'-Diol adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric excess (ee). Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as chiral purity (HPLC), chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.