Description

cis-Ethyl (2-Fluorocyclopropyl)-3-Oxopropanoate is a high-value fluorinated building block and chiral synthon of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the strained cyclopropane ring and the strategically placed fluorine atom, enabling precise stereochemical control and the introduction of fluorinated motifs. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to construct complex molecules for drug discovery and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in antiviral and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the development of novel, fluorinated herbicides, fungicides, and insecticides, where the fluorine atom can enhance bioavailability and metabolic stability.
• Advanced Material Research: Serves as a monomer or building block for creating specialty polymers and liquid crystals with tailored electronic and optical properties.
• Methodology Development: A valuable substrate in academic and industrial R&D for studying new fluorination, cyclopropanation, and asymmetric synthesis techniques.
• Peptidomimetics & Bioisosteres: The fluorocyclopropyl group is used as a rigid, metabolically stable bioisostere in the design of peptide analogs and enzyme inhibitors.

Basic Information

Product Name	cis-Ethyl (2-Fluorocyclopropyl)-3-Oxopropanoate
CAS No.	1706439-17-9
Molecular Formula	C8H11FO3
Molecular Weight	174.17 g/mol
Synonyms	Ethyl cis-2-fluorocyclopropane-1-carboxylate-3-oxopropanoate; Ethyl 3-oxo-3-((1R,2S)-2-fluorocyclopropyl)propanoate; (1R,2S)-Ethyl 2-fluorocyclopropanecarboxylate-3-oxopropanoate; 2-Fluorocyclopropanecarboxylic acid ethyl ester 3-oxopropanoate derivative; cis-2-Fluorocyclopropyl β-ketoester; FCPO ester; Fluorocyclopropyl ketoester
EINECS	Contact for details

Quality Control

Our cis-Ethyl (2-Fluorocyclopropyl)-3-Oxopropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.