Description

(S)-3,3'-Bis[3,5-Bis(trifluoromethyl)phenyl]-1,1'-binaphthyl-2,2'-diyl-n-tosyl phosphoramide is a sophisticated chiral phosphoramide ligand, a key building block in advanced asymmetric synthesis. Its core value lies in enabling highly enantioselective transformations, crucial for producing single-isomer pharmaceuticals and fine chemicals. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-performance, tunable catalysts for complex synthetic routes. CAS No. 1706437-52-6.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metal-catalyzed reactions, including hydrogenation, allylic alkylation, and hydroformylation.
• Pharmaceutical Intermediate Synthesis: Enabling the production of enantiomerically pure active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and oncology.
• Agrochemical Development: Used in the synthesis of chiral pesticides and herbicides where biological activity is often specific to one enantiomer.
• Methodology Research: A valuable tool for academic and industrial R&D in developing new catalytic systems and synthetic methodologies.
• Fine Chemical Production: Facilitating the manufacture of high-value chiral flavors, fragrances, and electronic chemicals.
• Ligand Library Construction: Serves as a sophisticated core structure for creating diverse ligand libraries for high-throughput catalyst screening.

Basic Information

Item	Detail
Product Name	(S)-3,3'-Bis[3,5-Bis(trifluoromethyl)phenyl]-1,1'-binaphthyl-2,2'-diyl-n-tosyl phosphoramide
CAS No.	1706437-52-6
Molecular Formula	C58H32F12NO5PS
Molecular Weight	1122.90 g/mol
Synonyms	(S)-BINOL-Derived Phosphoramide Ligand; (S)-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl Phosphoric Acid Tosylamide; (S)-BINAP-Ts Phosphoramide; (S)-DTBM-BINOL-Tosyl Phosphoramide; (S)-Tosyl Phosphoramide Ligand; Chiral Phosphoric Acid Amide Derivative; (S)-BINOL Phosphoramide Catalyst; Asymmetric Organocatalyst Ligand
EINECS	Contact for details

Quality Control

Every batch of our (S)-3,3'-Bis[3,5-Bis(trifluoromethyl)phenyl]-1,1'-binaphthyl-2,2'-diyl-n-tosyl phosphoramide is synthesized and purified under controlled conditions to ensure exceptional chiral purity and chemical integrity. We employ rigorous analytical protocols including HPLC, NMR, and chiral analysis to verify identity, purity, and enantiomeric excess (ee). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.