Description

5-Chloro-2,3-Dihydro-1H-Indole-2-Carboxylic Acid Methylamide is a high-purity, synthetically valuable indole derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in providing a functionalized indole scaffold essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals. Its specific structure makes it a versatile intermediate for medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Chemical Research & Development: Serves as a versatile building block for synthesizing complex indole-based libraries for high-throughput screening.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and advanced polymers requiring specific indole motifs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	5-Chloro-2,3-Dihydro-1H-Indole-2-Carboxylic Acid Methylamide
CAS No.	1706428-64-9
Molecular Formula	C10H11ClN2O
Molecular Weight	210.66 g/mol
Synonyms	5-Chloro-2,3-dihydro-1H-indole-2-carboxamide, N-methyl-; 5-Chloro-2,3-dihydro-N-methyl-1H-indole-2-carboxamide; Methyl 5-chloro-2,3-dihydro-1H-indole-2-carboxylate amide; 2-Carboxamide-5-chloro-2,3-dihydro-1H-indole, N-methyl-; (2S)-5-Chloro-2,3-dihydro-N-methyl-1H-indole-2-carboxamide (for enantiopure form); 1706428-64-9; 5-Chloroindoline-2-carboxylic acid methylamide.
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,3-Dihydro-1H-Indole-2-Carboxylic Acid Methylamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates, including those under research and cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.