Description

(4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-2-Fluorophenyl)Boronic Acid is a sophisticated, multifunctional boronic acid derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern pharmaceutical and agrochemical research, enabling the formation of carbon-carbon bonds via Suzuki-Miyaura cross-coupling reactions. Its unique spirocyclic and fluorinated structure makes it particularly valuable for medicinal chemists and process R&D teams developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective formation of biaryl bonds, a fundamental transformation in constructing complex molecular architectures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Serves as a monomer or functionalization agent in the creation of advanced polymers, OLED materials, and liquid crystals.
• Chemical Biology & Proteomics: Utilized in the design of probes and inhibitors that target proteins containing serine or threonine residues.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the cost-effective, large-scale manufacturing of fine chemicals.

Basic Information

Product Name	(4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-2-Fluorophenyl)Boronic Acid
CAS No.	1704121-92-5
Molecular Formula	C₁₇H₂₃BFNO₄
Molecular Weight	335.18 g/mol
Synonyms	2-Fluoro-4-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)phenylboronic acid; 4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-2-fluorobenzeneboronic acid; 2-Fluoro-4-[(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl]benzeneboronic acid; B-[4-[(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)methyl]-2-fluorophenyl]boronic acid; (4-((1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)methyl)-2-fluorophenyl)boronic acid; 1704121-92-5; AKOS040759414; FT-0772805.
EINECS	Contact for details

Quality Control

Our (4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-2-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.