Description

2-Chloro-N-(4-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for research and development chemists in the pharmaceutical and agrochemical industries, enabling the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex fluorinated biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a boronic ester coupling partner to form carbon-carbon bonds under mild conditions, critical for constructing drug-like molecules.
• Medicinal Chemistry Research: Enables the exploration of new chemical space in drug discovery programs, especially for kinase inhibitors, CNS agents, and anti-cancer compounds.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Potential use in the synthesis of organic electronic materials and ligands for catalysis.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex organic molecules.

Basic Information

Product Name	2-Chloro-N-(4-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Acetamide
CAS No.	1704121-67-4
Molecular Formula	C14H18BClFNO3
Molecular Weight	313.56 g/mol
Synonyms	2-Chloro-N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; N-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-chloroacetamide; 2-Chloroacetamide, N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, 2-chloroacetamide derivative; CAS 1704121-67-4; Boronic ester intermediate 1704121-67-4; Pinacol boronate acetamide derivative.
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-N-(4-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Acetamide adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling reactions. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We implement in-process controls and final release testing aligned with ICH guidelines to meet the exacting standards of pharmaceutical R&D and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.