Description

(5-(n-Cyclopropylsulfamoyl)-2-Fluoro-4-Methylphenyl)Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique sulfamoyl-cyclopropyl and boronic acid functional group. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel small molecule therapeutics through efficient cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of targeted drugs, particularly in oncology and metabolic disease research.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl scaffolds in drug discovery programs.
• Protease Inhibitor Development: Serves as a core structural motif in the synthesis of potential protease inhibitors, leveraging the boronic acid group's affinity for active sites.
• Kinase-Targeted Drug Candidates: Used in the research and synthesis of novel kinase inhibitors for cancer therapy.
• Chemical Biology Probes: Employed in the creation of activity-based probes for studying enzyme function and mechanism.
• Material Science Research: Investigated as a monomer or linker for creating novel organic frameworks or polymeric materials with specific functionalities.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the route development and cGMP manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(5-(n-Cyclopropylsulfamoyl)-2-Fluoro-4-Methylphenyl)Boronic Acid
CAS No.	1704121-43-6
Molecular Formula	C10H13BFNO4S
Molecular Weight	285.09 g/mol
Synonyms	[5-(Cyclopropylsulfamoyl)-2-fluoro-4-methylphenyl]boronic acid; 2-Fluoro-4-methyl-5-(N-cyclopropylsulfamoyl)phenylboronic acid; B-[5-(Cyclopropylsulfamoyl)-2-fluoro-4-methylphenyl]boronic acid; 5-(N-Cyclopropylsulfamoyl)-2-fluoro-4-methylbenzeneboronic acid; 1704121-43-6; Boronic acid, B-[5-[(cyclopropylamino)sulfonyl]-2-fluoro-4-methylphenyl]-; (5-Cyclopropylsulfamoyl-2-fluoro-4-methylphenyl)boronic acid
EINECS	Contact for details

Quality Control

Our (5-(n-Cyclopropylsulfamoyl)-2-Fluoro-4-Methylphenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with ICH Q7 guidelines for pharmaceutical intermediates, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.