Description

n-(2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-2-Morpholinoacetamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, a critical functional handle for modern cross-coupling reactions. This compound is essential for medicinal chemistry research and development, enabling the efficient synthesis of complex molecules through Suzuki-Miyaura coupling. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on creating novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronate ester moiety serves as a crucial coupling partner for forming carbon-carbon bonds with aryl halides, a cornerstone of modern medicinal chemistry.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize lead compounds.
• API Development: Integral to the process research and development (PR&D) and scale-up phases for new active pharmaceutical ingredients.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for target identification and validation in biological systems.
• Fine Chemical Synthesis: Serves as a specialized intermediate for synthesizing complex, high-value organic molecules beyond pharmaceuticals.

Basic Information

Product Name	n-(2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-2-Morpholinoacetamide
CAS No.	1704121-22-1
Molecular Formula	C18H26BFN2O4
Molecular Weight	364.22 g/mol
Synonyms	2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2-morpholinoacetyl)aniline; 2-Morpholino-N-[2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 1704121-22-1; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl-2-morpholinoacetamide; Boronic acid, B-[4-[(2-morpholinoacetyl)amino]-3-fluorophenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our n-(2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-2-Morpholinoacetamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization including HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.