Description

2-Chloro-N-(2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel small-molecule therapeutics and functional organic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, crucial for constructing complex biaryl structures.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Material Science: Intermediate for the synthesis of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Proteomics: Utilized as a probe or linker in the development of chemical tools for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research and development projects.

Basic Information

Product Name	2-Chloro-N-(2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide
CAS No.	1704121-19-6
Molecular Formula	C14H18BClFNO3
Molecular Weight	313.56 g/mol
Synonyms	2-Chloro-N-[2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, N-(chloroacetyl)-; 1704121-19-6; (5-((2-Chloroacetamido)-2-fluorophenyl)boronic acid pinacol ester; 2-Chloroacetamide, N-[2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; Boronic acid, B-[5-[(2-chloroacetyl)amino]-2-fluorophenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-N-(2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.