Description

(5-(((2,4-Dimethoxybenzyl)Amino)Methyl)-2-Fluorophenyl)Boronic Acid is a sophisticated boronic acid derivative featuring a fluorinated aromatic core and a dimethoxybenzyl-protected amine linker. This compound matters as a high-value pharmaceutical intermediate and cross-coupling reagent, essential for constructing complex molecules in modern synthetic chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications such as Suzuki-Miyaura cross-coupling reactions and the synthesis of bioactive compounds.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug candidates.
• Suzuki-Miyaura Cross-Coupling Reagent: Used in palladium-catalyzed reactions to form carbon-carbon bonds, enabling the construction of complex biaryl structures common in modern drug molecules.
• Agrochemical Research & Development: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require fluorinated aromatic components.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands and organoboron catalysts used in asymmetric synthesis.
• Material Science & OLED Research: Utilized in the development of organic electronic materials, where fluorinated and boron-containing compounds can tune electronic properties.
• Protease Inhibitor Scaffolds: The boronic acid moiety can be instrumental in designing potent inhibitors for proteolytic enzymes.

Basic Information

Item	Details
Product Name	(5-(((2,4-Dimethoxybenzyl)Amino)Methyl)-2-Fluorophenyl)Boronic Acid
CAS No.	1704121-14-1
Molecular Formula	C16H19BFNO4
Molecular Weight	319.14 g/mol
Synonyms	5-[(2,4-Dimethoxybenzylamino)methyl]-2-fluorobenzeneboronic acid; 2-Fluoro-5-[[(2,4-dimethoxybenzyl)amino]methyl]phenylboronic acid; (5-(((2,4-Dimethoxybenzyl)Amino)Methyl)-2-Fluorophenyl)Boronic Acid Pinacol Ester (common protected form); Boronic acid, B-[5-[[[(2,4-dimethoxyphenyl)methyl]amino]methyl]-2-fluorophenyl]-; 1704121-14-1; DMB-Protected Fluoro Phenyl Boronic Acid Derivative
EINECS	Contact for details

Quality Control

Our (5-(((2,4-Dimethoxybenzyl)Amino)Methyl)-2-Fluorophenyl)Boronic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development from milligram to kilogram scale with consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool, and well-ventilated place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.