Description

(2-Fluoro-5-((4-Hydroxypiperidin-1-yl)sulfonyl)phenyl)boronic acid is a high-purity, advanced pharmaceutical intermediate featuring a unique sulfonamide-linked piperidine and boronic acid pharmacophore. This compound matters for its critical role in modern medicinal chemistry, particularly in the development of targeted covalent inhibitors and proteolysis-targeting chimeras (PROTACs) via Suzuki-Miyaura cross-coupling reactions. Pharmaceutical R&D teams and fine chemical manufacturers need this specialized boronic acid for synthesizing novel drug candidates targeting kinases and other disease-relevant proteins.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of covalent kinase inhibitors and other targeted therapeutics.
• PROTAC Linker Component: Utilized in the construction of Proteolysis-Targeting Chimeras (PROTACs) due to its bifunctional structure.
• Suzuki-Miyaura Cross-Coupling: Essential boronic acid partner for palladium-catalyzed carbon-carbon bond formation in complex molecule assembly.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new chemical entities.
• Bioconjugation: Potential application in labeling and modifying biomolecules via reactions with the boronic acid group.
• Chemical Biology Probes: Serves as a precursor for activity-based probes to study enzyme function and inhibition.

Basic Information

Product Name	(2-Fluoro-5-((4-Hydroxypiperidin-1-yl)sulfonyl)phenyl)boronic Acid
CAS No.	1704096-91-2
Molecular Formula	C11H15BFNO5S
Molecular Weight	303.12 g/mol
Synonyms	1-(3-Fluoro-4-boronophenylsulfonyl)-4-hydroxypiperidine; [2-Fluoro-5-(4-hydroxypiperidine-1-sulfonyl)phenyl]boronic acid; B-[2-Fluoro-5-[(4-hydroxy-1-piperidinyl)sulfonyl]phenyl]boronic acid; 2-Fluoro-5-(4-hydroxypiperidine-1-sulfonyl)benzeneboronic acid; 1-[(2-Fluoro-5-boronophenyl)sulfonyl]-4-piperidinol; Boronic acid, B-[2-fluoro-5-[(4-hydroxy-1-piperidinyl)sulfonyl]phenyl]-; 1704096-91-2
EINECS	Contact for details

Quality Control

Our (2-Fluoro-5-((4-Hydroxypiperidin-1-yl)sulfonyl)phenyl)boronic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.