Description

(4-((4-((tert-Butyldiphenylsilyl)Oxy)Piperidin-1-Yl)Methyl)-2-Fluorophenyl)Boronic Acid is a sophisticated, high-purity boronic acid derivative featuring a protected piperidine scaffold, designed for advanced synthetic applications. Its core value lies in serving as a critical building block and Suzuki-Miyaura cross-coupling partner for the construction of complex molecules, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for targets containing fluorinated biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid coupling partner for forming carbon-carbon bonds with aryl/heteroaryl halides, a cornerstone of modern medicinal chemistry.
• Protease Inhibitor Research: The piperidine moiety makes it valuable for constructing potential inhibitors for various proteolytic enzymes.
• Kinase Inhibitor Development: Used in the synthesis of complex heterocyclic scaffolds targeting kinase proteins in oncology and other therapeutic areas.
• Chemical Biology & Probe Development: Employed in creating molecular probes and tools for studying biological pathways and target engagement.
• Agrochemical Synthesis: Intermediate for developing novel herbicides, fungicides, or insecticides with fluorinated aromatic systems.
• Advanced Material Precursor: Potential building block for organic electronic materials or metal-organic frameworks (MOFs) requiring specific ligand geometries.

Basic Information

Product Name	(4-((4-((tert-Butyldiphenylsilyl)Oxy)Piperidin-1-Yl)Methyl)-2-Fluorophenyl)Boronic Acid
CAS No.	1704096-87-6
Molecular Formula	C29H37BFO3Si
Molecular Weight	491.51 g/mol
Synonyms	2-Fluoro-4-((4-((tert-butyldiphenylsilyl)oxy)piperidin-1-yl)methyl)phenylboronic acid; (4-((4-(tert-Butyldiphenylsilyloxy)piperidin-1-yl)methyl)-2-fluorophenyl)boronic acid; 1-(4-(tert-Butyldiphenylsilyloxy)piperidin-1-yl)methyl)-2-fluorophenyl-4-boronic acid; B-[4-[[4-[(1,1-Dimethylethyl)diphenylsilyl]oxy]-1-piperidinyl]methyl]-2-fluorophenyl]boronic acid; TBDPS-protected piperidine boronic acid derivative; CAS 1704096-87-6; (4-((4-(TBDPS-Oxy)Piperidin-1-Yl)Methyl)-2-Fluorophenyl)Boronic Acid
EINECS	Contact for details

Quality Control

Our (4-((4-((tert-Butyldiphenylsilyl)Oxy)Piperidin-1-Yl)Methyl)-2-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical characterization including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere (argon or nitrogen) after each use to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.