Description

(4-Fluoro-3-(4-Oxopiperidine-1-Carbonyl)Phenyl)Boronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in its dual functionality, combining a reactive boronic acid group for Suzuki-Miyaura cross-coupling with a complex, fluorinated piperidinone-based scaffold, enabling the construction of novel, structurally diverse molecules. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of new active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: Utilized in palladium-catalyzed reactions to form carbon-carbon bonds, enabling the efficient construction of biaryl and heterobiaryl structures common in modern medicinal chemistry.
• Agrochemical Research: Employed in the discovery and development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Used in the synthesis of organic electronic materials, such as those for organic light-emitting diodes (OLEDs) and semiconductors, where the fluorinated aromatic system can enhance stability and performance.
• Chemical Biology Probe Development: Serves as a versatile handle for creating activity-based probes and molecular tags to study biological processes and protein interactions.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries to identify new lead structures in drug discovery campaigns.

Basic Information

Product Name	(4-Fluoro-3-(4-Oxopiperidine-1-Carbonyl)Phenyl)Boronic Acid
CAS No.	1704082-33-6
Molecular Formula	C13H15BFNO4
Molecular Weight	287.08 g/mol
Synonyms	[4-Fluoro-3-(4-oxopiperidine-1-carbonyl)phenyl]boronic acid; 1-[2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]piperidin-4-one (Pinacol Ester); 3-(4-Oxo-1-piperidinecarbonyl)-4-fluorobenzeneboronic Acid; B-[4-Fluoro-3-(4-oxo-1-piperidinylcarbonyl)phenyl]boronic Acid; 4-Fluoro-3-(4-oxopiperidine-1-carbonyl)benzeneboronic Acid; 1704082-33-6; AKOS026712293
EINECS	Contact for details

Quality Control

Our (4-Fluoro-3-(4-Oxopiperidine-1-Carbonyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D and process chemistry. Comprehensive Certificates of Analysis (COA) with full traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF Titration)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.