Description

(3-Fluoro-4-(3-(Piperazin-1-Yl)Propoxy)Phenyl)Boronic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate and key building block in modern synthetic chemistry. Its core value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a piperazine moiety that offers versatile nitrogen-based pharmacophore potential. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel small-molecule therapeutics, kinase inhibitors, and other complex organic targets.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology and CNS drug discovery programs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to create complex biaryl structures, a cornerstone reaction in medicinal chemistry.
• Kinase Inhibitor Development: The piperazine and boronic acid motifs are common in the design of potent and selective kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides requiring specific aromatic and heterocyclic architectures.
• Material Science Research: Serves as a precursor for creating organic electronic materials and metal-organic frameworks (MOFs) with tailored properties.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	(3-Fluoro-4-(3-(Piperazin-1-Yl)Propoxy)Phenyl)Boronic Acid Hydrochloride
CAS No.	1704082-00-7
Molecular Formula	C13H21BFNO3 • HCl
Molecular Weight	329.58 g/mol (Free base: 293.12 g/mol)
Synonyms	(3-Fluoro-4-(3-(1-Piperazinyl)propoxy)phenyl)boronic acid hydrochloride; 4-(3-(Piperazin-1-yl)propoxy)-3-fluorophenylboronic acid HCl; B-[3-Fluoro-4-[3-(1-piperazinyl)propoxy]phenyl]boronic acid hydrochloride; 3-Fluoro-4-(3-piperazin-1-yl-propoxy)benzeneboronic acid hydrochloride; 1704082-00-7; Boronic acid, B-[3-fluoro-4-[3-(1-piperazinyl)propoxy]phenyl]-, hydrochloride
EINECS	Contact for details

Quality Control

Our (3-Fluoro-4-(3-(Piperazin-1-Yl)Propoxy)Phenyl)Boronic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure compliance with stringent industry standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.