Description

(4-Fluoro-3-(4-Hydroxypiperidine-1-Carbonyl)Phenyl)Boronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a hydroxypiperidine-carbonyl moiety that offers a handle for further derivatization and solubility modulation. This compound is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of complex molecules, including potential active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functional group enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, essential for constructing biaryl scaffolds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand Synthesis for Catalysis: The hydroxypiperidine moiety can be utilized to create novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Serves as a monomer or functionalizing agent in the creation of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Item	Details
Product Name	(4-Fluoro-3-(4-Hydroxypiperidine-1-Carbonyl)Phenyl)Boronic Acid
CAS No.	1704080-43-2
Molecular Formula	C12H15BFNO4
Molecular Weight	279.07 g/mol
Synonyms	[4-Fluoro-3-(4-hydroxypiperidine-1-carbonyl)phenyl]boronic acid; (4-Fluoro-3-((4-hydroxypiperidin-1-yl)carbonyl)phenyl)boronic acid; B-[4-Fluoro-3-(4-hydroxy-1-piperidinylcarbonyl)phenyl]boronic acid; 3-Carboxy-4-fluorophenylboronic acid 4-hydroxypiperidine amide; 1704080-43-2; Boronic acid, B-[4-fluoro-3-[(4-hydroxy-1-piperidinyl)carbonyl]phenyl]-; AKOS026713293
EINECS	Contact for details

Quality Control

Our (4-Fluoro-3-(4-Hydroxypiperidine-1-Carbonyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. Due to its hygroscopic nature, the container should be sealed under dry conditions and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.