Description

(3-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-5-Fluorophenyl)Boronic Acid is a sophisticated boronic acid derivative featuring a spirocyclic acetal-protected diol and a tertiary amine, making it a valuable building block for modern synthetic chemistry. This compound is specifically engineered for use in cross-coupling reactions, most notably the Suzuki-Miyaura reaction, which is fundamental for constructing complex biaryl structures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers in the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron-containing partner for palladium-catalyzed carbon-carbon bond formation to create complex biaryl and heterobiaryl scaffolds.
• Agrochemical Research: Used in the development of new herbicides and fungicides with enhanced efficacy and selectivity.
• Material Science: Employed in the creation of organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Can be utilized in the synthesis of molecular probes and affinity ligands for studying protein interactions.
• Library Synthesis: An important building block for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Product Name	(3-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-5-Fluorophenyl)Boronic Acid
CAS No.	1704074-61-2
Molecular Formula	C₁₆H₂₁BFNO₄
Molecular Weight	321.16 g/mol
Synonyms	5-Fluoro-3-[(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]benzeneboronic acid; [3-[(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-5-fluorophenyl]boronic acid; (5-Fluoro-3-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)phenyl)boronic acid; Boronic acid, B-[3-[(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-5-fluorophenyl]-; 3-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-5-fluorobenzeneboronic acid; 1704074-61-2; CAS 1704074-61-2
EINECS	Contact for details

Quality Control

Our (3-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-5-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.