Description

(4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-3-Fluorophenyl)Boronic Acid is a sophisticated, multifunctional organoboron building block designed for advanced synthetic chemistry. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and this boronic acid derivative, crucial for synthesizing complex biaryl structures.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, due to its spirocyclic and fluorinated motifs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the specific spatial arrangement and fluorine atom can enhance biological activity and stability.
• Material Science & OLED Development: Employed in creating novel organic semiconductors, ligands for catalysts, and emissive layers in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Synthesis: Facilitates the creation of molecular probes and labeled compounds for studying biological pathways and protein interactions.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis of diverse compound libraries for screening against novel biological targets.

Basic Information

Product Name	(4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-3-Fluorophenyl)Boronic Acid
CAS No.	1704074-38-3
Molecular Formula	C16H21BFNO4
Molecular Weight	321.15 g/mol
Synonyms	3-Fluoro-4-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)benzeneboronic acid; (3-Fluoro-4-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methyl)phenyl)boronic acid; B-[4-[(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-3-fluorophenyl]boronic acid; 4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-3-fluorobenzeneboronic acid; 1704074-38-3; Boronic acid, B-[4-[(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)methyl]-3-fluorophenyl]-; Spirocyclic fluorophenylboronic acid derivative
EINECS	Contact for details

Quality Control

Our (4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylmethyl)-3-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.