Description

(2-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylsulfonyl)-4,5-Difluorophenyl)Boronic Acid is a sophisticated, multifunctional boronic acid derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern pharmaceutical and agrochemical research, enabling the formation of carbon-carbon bonds via the versatile Suzuki-Miyaura cross-coupling reaction. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as an essential boronic acid coupling partner for constructing biaryl and heterobiaryl structures, a cornerstone of modern medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Potential building block for creating advanced organic electronic materials and functional polymers.
• Chemical Biology & Proteomics: Can be employed in the development of molecular probes and affinity ligands for studying biological systems.
• Process Chemistry & Scale-up: Supports the development of robust, scalable synthetic routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	(2-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylsulfonyl)-4,5-Difluorophenyl)Boronic Acid
CAS No.	1704074-09-8
Molecular Formula	C15H18BF2NO6S
Molecular Weight	397.18 g/mol
Synonyms	4,5-Difluoro-2-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)sulfonyl)benzeneboronic acid; 2-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)-4,5-difluorobenzeneboronic acid; 4,5-Difluoro-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)phenylboronic acid; (4,5-Difluoro-2-((1,4-dioxa-8-azaspiro[4.5]decan-8-yl)sulfonyl)phenyl)boronic acid; CAS 1704074-09-8; Boronic acid, B-[4,5-difluoro-2-[(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)sulfonyl]phenyl]-
EINECS	Contact for details

Quality Control

Our (2-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylsulfonyl)-4,5-Difluorophenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.