Description

3-(Cyclopropylcarbamoyl)-5-Fluorophenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its dual functionality, serving as a versatile intermediate in cross-coupling reactions and as a key precursor for the synthesis of complex bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of new active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the fluorophenyl moiety for enhanced biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, organic electronic materials, and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Employed in the synthesis of chemical probes and affinity ligands for studying enzyme function and protein-protein interactions.
• Catalyst Ligand Precursor: Used to synthesize specialized ligands for transition metal catalysts employed in asymmetric synthesis and fine chemical manufacturing.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-(Cyclopropylcarbamoyl)-5-Fluorophenylboronic Acid
CAS No.	1704074-07-6
Molecular Formula	C10H11BFNO3
Molecular Weight	222.01 g/mol
Synonyms	[3-(Cyclopropylcarbamoyl)-5-fluorophenyl]boronic acid; 5-Fluoro-3-(cyclopropylcarbamoyl)benzeneboronic acid; 3-Fluoro-5-boronobenzoylcyclopropylamide; Boronic acid, B-[3-[(cyclopropylamino)carbonyl]-5-fluorophenyl]-; 1704074-07-6; 3-Cyclopropylcarbamoyl-5-fluorophenylboronic acid; 5-Fluoro-N-cyclopropyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (Pinacol ester precursor)
EINECS	Contact for details

Quality Control

Our 3-(Cyclopropylcarbamoyl)-5-Fluorophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%
Boron Content	4.7 - 5.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.