Description

2-Fluoro-3-(Morpholine-4-Carbonyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a reactive boronic acid group for Suzuki-Miyaura cross-coupling reactions with a fluorinated aromatic ring and a morpholine amide moiety, enabling precise structural modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in developing novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in constructing novel herbicide and pesticide molecules, leveraging the fluorine atom for enhanced metabolic stability and bioavailability.
• Material Science: Employed in the development of advanced organic electronic materials, such as OLEDs and semiconductors, where the specific electronic properties of the fluorinated arylboronic acid are advantageous.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl structures, a cornerstone reaction in medicinal chemistry.
• Chemical Biology Probes: Serves as a building block for creating molecular probes and inhibitors used to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for drug discovery campaigns.

Basic Information

Product Name	2-Fluoro-3-(Morpholine-4-Carbonyl)Phenylboronic Acid
CAS No.	1704074-05-4
Molecular Formula	C11H13BFNO4
Molecular Weight	277.04 g/mol
Synonyms	[2-Fluoro-3-(morpholine-4-carbonyl)phenyl]boronic acid; 2-Fluoro-3-(4-morpholinylcarbonyl)benzeneboronic acid; 3-Borono-2-fluorobenzoic acid morpholide; (2-Fluoro-3-morpholinocarbonylphenyl)boronic acid; B-[2-Fluoro-3-(morpholine-4-carbonyl)phenyl]boronic acid; 1704074-05-4; AKOS026710293; FT-0773787
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-(Morpholine-4-Carbonyl)Phenylboronic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Assay	≥95.0% (by titration)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.