Description

(3-(4-((tert-Butyldimethylsilyl)Oxy)Piperidin-1-Yl)-5-Fluorophenyl)Boronic Acid is a sophisticated, high-value boronic acid derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern pharmaceutical research and development, enabling the construction of complex molecular architectures. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating novel active pharmaceutical ingredients (APIs).

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds, essential for constructing biaryl and heterobiaryl scaffolds prevalent in drug molecules.
• Pharmaceutical Intermediate Synthesis: Serves as a pivotal precursor in the multi-step synthesis of potential therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.
• Medicinal Chemistry & Lead Optimization: Used to introduce the fluorinated piperidine-boronic acid moiety into candidate compounds to fine-tune pharmacokinetic properties like metabolic stability and bioavailability.
• Process Chemistry & Scale-Up: Employed in the development of robust and efficient manufacturing routes for target molecules at pilot and commercial scales.
• Library Synthesis for High-Throughput Screening: Facilitates the rapid generation of diverse compound libraries to identify new hits in drug discovery campaigns.
• Agrochemical Research: Potential application in the synthesis of novel herbicides or fungicides containing complex fluorinated heterocycles.
• Materials Science Precursor: Can be utilized in the synthesis of organic electronic materials or metal-organic frameworks (MOFs) requiring specific boronic acid functionalities.

Basic Information

Product Name	(3-(4-((tert-Butyldimethylsilyl)Oxy)Piperidin-1-Yl)-5-Fluorophenyl)Boronic Acid
CAS No.	1704073-45-9
Molecular Formula	C17H28BFNO3Si
Molecular Weight	351.31 g/mol
Synonyms	5-Fluoro-3-[4-[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-piperidinyl]benzeneboronic acid; (3-(4-((tert-Butyldimethylsilyl)oxy)piperidin-1-yl)-5-fluorophenyl)boronic acid; 1-(3-Borono-5-fluorophenyl)-4-[(tert-butyldimethylsilyl)oxy]piperidine; 4-[(tert-Butyldimethylsilyl)oxy]-1-(5-fluoro-3-boronophenyl)piperidine; B-[3-[4-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-piperidinyl]-5-fluorophenyl]boronic acid; TBDMS-protected 4-Hydroxypiperidine Boronic Acid Ester Derivative
EINECS	Contact for details

Quality Control

Our (3-(4-((tert-Butyldimethylsilyl)Oxy)Piperidin-1-Yl)-5-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliable consistency and traceability for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a desiccated environment to prevent moisture absorption, which can affect stability and reactivity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.