Description

(3-((tert-Butoxycarbonyl)Amino)-4-Fluorophenyl)Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a versatile boronic acid functional group. This compound is critical for the synthesis of complex molecules, particularly in the development of targeted therapeutics and novel chemical entities. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, proteolysis-targeting chimera (PROTAC) development, and Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those targeting kinase inhibition.
• PROTAC Development: Serves as a crucial linker component in the design and synthesis of Proteolysis-Targeting Chimeras due to its bifunctional nature.
• Suzuki-Miyaura Cross-Coupling: The boronic acid moiety enables efficient palladium-catalyzed carbon-carbon bond formation for constructing biaryl structures in complex organic synthesis.
• Medicinal Chemistry & SAR Studies: Used for structure-activity relationship (SAR) exploration to optimize the potency and selectivity of lead compounds.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological pathways and protein functions.
• Material Science Research: Potential precursor for novel organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Item	Detail
Product Name	(3-((tert-Butoxycarbonyl)Amino)-4-Fluorophenyl)Boronic Acid
CAS No.	1704069-72-6
Molecular Formula	C11H15BFNO4
Molecular Weight	255.05 g/mol
Synonyms	N-Boc-3-Amino-4-fluorophenylboronic Acid; 3-((tert-Butoxycarbonyl)amino)-4-fluorobenzeneboronic acid; 4-Fluoro-3-((tert-butoxycarbonyl)amino)phenylboronic acid; BOC-3-Amino-4-Fluorophenylboronic Acid; 3-(Boc-amino)-4-fluorophenylboronic acid; N-Boc-4-Fluoro-3-aminophenylboronic Acid; (3-(Boc-amino)-4-fluorophenyl)boronic acid
EINECS	Contact for details

Quality Control

Our (3-((tert-Butoxycarbonyl)Amino)-4-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.