Description

3-Fluoro-4-(4-Oxopiperidine-1-Carbonyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, combining a boronic acid moiety with a fluorinated aromatic ring and a piperidinone carbonyl group, makes it an invaluable reagent for constructing complex molecular architectures. This high-purity intermediate is primarily sought after by pharmaceutical and agrochemical research organizations for the development of new active ingredients, particularly through Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for creating biaryl and heterobiaryl structures essential in medicinal chemistry.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology: Utilized as a probe or linker in the development of enzyme inhibitors and protein-binding molecules.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	3-Fluoro-4-(4-Oxopiperidine-1-Carbonyl)Phenylboronic Acid
CAS No.	1704069-68-0
Molecular Formula	C13H15BFNO4
Molecular Weight	279.08 g/mol
Synonyms	[3-Fluoro-4-(4-oxopiperidine-1-carbonyl)phenyl]boronic acid; 1-[4-(3-Fluoro-4-boronophenyl)carbonyl]-4-piperidinone; 3-Fluoro-4-(4-oxo-1-piperidinecarbonyl)benzeneboronic acid; (3-Fluoro-4-((4-oxopiperidin-1-yl)carbonyl)phenyl)boronic acid; Boronic acid, B-[3-fluoro-4-[(4-oxo-1-piperidinyl)carbonyl]phenyl]-; 1704069-68-0; CAS 1704069-68-0
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(4-Oxopiperidine-1-Carbonyl)Phenylboronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ICH Q7 guidelines, and REACH regulations for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.