Description

(3-(2,2,2-Trifluoroethoxy)-5-(Trifluoromethyl)Phenyl)Boronic Acid is a high-value, multi-fluorinated boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where its unique trifluoromethyl and trifluoroethoxy substituents are leveraged to fine-tune the metabolic stability, lipophilicity, and bioavailability of target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Employed in the development of novel organic electronic materials, liquid crystals, and polymers with specific optical or electronic properties.
• Suzuki-Miyaura Cross-Coupling: Functions as a versatile boronic acid partner for forming carbon-carbon bonds between aromatic rings, a fundamental reaction in medicinal and process chemistry.
• PET (Positron Emission Tomography) Tracer Development: Potential use in synthesizing fluorine-18 labeled compounds for diagnostic imaging.
• Chemical Biology & Proteomics: Can be utilized as a handle for bioconjugation or in the synthesis of molecular probes for studying biological systems.

Basic Information

Product Name	(3-(2,2,2-Trifluoroethoxy)-5-(Trifluoromethyl)Phenyl)Boronic Acid
CAS No.	1704069-50-0
Molecular Formula	C10H7BF6O3
Molecular Weight	300.97 g/mol
Synonyms	[3-(2,2,2-Trifluoroethoxy)-5-(trifluoromethyl)phenyl]boronic acid; 3-(2,2,2-Trifluoroethoxy)-5-(trifluoromethyl)benzeneboronic acid; (3-Trifluoroethoxy-5-trifluoromethylphenyl)boronic acid; Boronic acid, B-[3-(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)phenyl]-; 5-Trifluoromethyl-3-trifluoroethoxybenzeneboronic acid; 3-Trifluoromethoxy-5-trifluoromethylphenylboronic acid (common variant); 3-(Trifluoroethoxy)-5-(trifluoromethyl)phenylboronic acid
EINECS	Contact for details

Quality Control

Our (3-(2,2,2-Trifluoroethoxy)-5-(Trifluoromethyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and support your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.