Description

4-((4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3-Dioxolan-2-Yl)Phenyl)Sulfonyl)Morpholine is a high-value, advanced pharmaceutical intermediate characterized by its complex sulfonyl morpholine and protected boronic ester functional groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted small-molecule therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel drug candidates, particularly in oncology and central nervous system (CNS) disease research. The CAS number for this product is 1704069-32-8.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) for investigational new drugs.
• Suzuki-Miyaura Cross-Coupling Reactions: The tetramethyl-1,3-dioxolan-2-yl group is a protected form of a boronic acid/ester, making this compound a crucial coupling partner in palladium-catalyzed reactions to form biaryl bonds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop molecules with improved potency and pharmacokinetic properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use as a component in the linker or warhead sections of bifunctional degraders.
• Chemical Biology Probes: Can be utilized to create tool compounds for studying specific biological pathways and target validation.

Basic Information

Item	Detail
Product Name	4-((4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3-Dioxolan-2-Yl)Phenyl)Sulfonyl)Morpholine
CAS No.	1704069-32-8
Molecular Formula	C17H24FNO5S
Molecular Weight	373.44 g/mol
Synonyms	4-[(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl]morpholine; 2-(4-Fluoro-2-(morpholinosulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(2-(morpholinosulfonyl)-5-fluorophenyl)-1,3,2-dioxaborolane; 1704069-32-8; 4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl morpholinosulfone
EINECS	Contact for details

Quality Control

Our 4-((4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3-Dioxolan-2-Yl)Phenyl)Sulfonyl)Morpholine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.