Description

(4,5-Difluoro-2-((4-Hydroxypiperidin-1-Yl)Sulfonyl)Phenyl)Boronic Acid is a sophisticated boronic acid derivative featuring a sulfonyl piperidine moiety, making it a high-value building block for modern synthetic chemistry. Its core value lies in its dual functionality, serving as both a versatile coupling partner in Suzuki-Miyaura cross-couplings and a key intermediate for constructing complex pharmacophores. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting kinase inhibitors and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reagent: Utilized as a key boronic acid component in palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures, which are prevalent in medicinal chemistry.
• Agrochemical Synthesis: Serves as an advanced intermediate in the research and development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Used in the development of organic electronic materials, such as polymers and molecular semiconductors, where its specific structure can tune electronic properties.
• Chemical Biology & Proteomics: Acts as a potential ligand or probe in the development of chemical tools for studying biological systems and protein function.
• Library Synthesis for High-Throughput Screening: Employed in combinatorial chemistry to create diverse compound libraries for biological activity screening.

Basic Information

Product Name	(4,5-Difluoro-2-((4-Hydroxypiperidin-1-Yl)Sulfonyl)Phenyl)Boronic Acid
CAS No.	1704069-01-1
Molecular Formula	C11H14BF2NO5S
Molecular Weight	329.11 g/mol
Synonyms	[4,5-Difluoro-2-[(4-hydroxypiperidin-1-yl)sulfonyl]phenyl]boronic acid; 1-(4,5-Difluoro-2-boronophenylsulfonyl)-4-hydroxypiperidine; 2-((4-Hydroxypiperidin-1-yl)sulfonyl)-4,5-difluorophenylboronic acid; Boronic acid, B-[4,5-difluoro-2-[(4-hydroxy-1-piperidinyl)sulfonyl]phenyl]-; (4,5-Difluoro-2-((4-hydroxypiperidin-1-yl)sulfonyl)phenyl)boronic acid; CAS 1704069-01-1
EINECS	Contact for details

Quality Control

Our (4,5-Difluoro-2-((4-Hydroxypiperidin-1-Yl)Sulfonyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.