Description

(3,4-Difluoro-5-(4-Methylpiperazin-1-Yl)Phenyl)Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique boronic acid functional group on a difluorinated phenyl ring substituted with a methylpiperazine moiety. This compound is of critical importance in modern medicinal chemistry, primarily serving as a key building block in the synthesis of complex small-molecule drug candidates via Suzuki-Miyaura cross-coupling reactions. It is essential for research and development chemists in the pharmaceutical and biotechnology sectors who are developing novel therapeutics, particularly in areas such as kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially in oncology and CNS research.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to attach complex aryl groups, a fundamental step in constructing diverse chemical libraries for drug discovery.
• Kinase Inhibitor Development: Used in the research and synthesis of potential kinase inhibitors, leveraging the specific steric and electronic properties of the difluoro and methylpiperazine motifs.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a linker or component in the design of bifunctional molecules for targeted protein degradation.
• Agrochemical Research: Employed in the discovery of new active ingredients with enhanced properties due to the fluorine atoms and heterocyclic amine.
• Material Science Precursor: Potential use in creating organic electronic materials or metal-organic frameworks (MOFs) where the boronic acid group facilitates polymerization or coordination.

Basic Information

Product Name	(3,4-Difluoro-5-(4-Methylpiperazin-1-Yl)Phenyl)Boronic Acid
CAS No.	1704068-73-4
Molecular Formula	C11H15BF2N2O2
Molecular Weight	256.06 g/mol
Synonyms	[3,4-Difluoro-5-(4-methyl-1-piperazinyl)phenyl]boronic acid; 5-(4-Methylpiperazin-1-yl)-3,4-difluorobenzeneboronic acid; (3,4-Difluoro-5-(4-methylpiperazin-1-yl)phenyl)boronic acid; Boronic acid, B-[3,4-difluoro-5-(4-methyl-1-piperazinyl)phenyl]-; 3,4-Difluoro-5-(4-methylpiperazin-1-yl)benzeneboronic acid; 1704068-73-4; CAS 1704068-73-4
EINECS	Contact for details

Quality Control

Our (3,4-Difluoro-5-(4-Methylpiperazin-1-Yl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support development and production needs with consistent quality that meets the stringent requirements for pharmaceutical R&D and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.