Description

(3-(Cyclopropylamino)-4,5-Difluorophenyl)Boronic Acid is a specialized organoboron compound featuring a cyclopropylamino substituent and difluorophenyl core, serving as a crucial building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluorophenyl moiety often enhances biological activity and metabolic stability.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers for OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic acid component for palladium-catalyzed C-C bond formation, allowing for the precise assembly of complex, functionalized biaryl and heterobiaryl scaffolds.
• Ligand and Catalyst Development: Utilized as a starting material for synthesizing novel bidentate ligands and organometallic catalysts.
• Chemical Biology & Probe Development: Acts as a building block for creating molecular probes and tags used in bioimaging and target identification studies.

Basic Information

Item	Details
Product Name	(3-(Cyclopropylamino)-4,5-Difluorophenyl)Boronic Acid
CAS No.	1704068-53-0
Molecular Formula	C9H10BF2NO2
Molecular Weight	213.00 g/mol
Synonyms	[3-(Cyclopropylamino)-4,5-difluorophenyl]boronic acid; (3-Cyclopropylamino-4,5-difluorophenyl)boronic acid; 4,5-Difluoro-3-(cyclopropylamino)benzeneboronic acid; B-[3-(Cyclopropylamino)-4,5-difluorophenyl]boronic acid; Boronic acid, B-[3-(cyclopropylamino)-4,5-difluorophenyl]-; 1704068-53-0; 3-Cyclopropylamino-4,5-difluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our (3-(Cyclopropylamino)-4,5-Difluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.