Description

(4,5-Difluoro-2-((4-Methylpiperidin-1-Yl)Sulfonyl)Phenyl)Boronic Acid is a sophisticated boronic acid derivative featuring a sulfonylpiperidine substituent, designed for advanced synthetic applications. This compound is a critical high-value building block in modern pharmaceutical and agrochemical research, enabling the formation of carbon-carbon bonds via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its unique difluoro and sulfonamide motifs for bioactivity.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for constructing biaryl and heterobiaryl structures essential in medicinal chemistry.
• Material Science Exploration: Investigated as a monomer or functional additive in the creation of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale manufacturing of complex molecules.

Basic Information

Product Name	(4,5-Difluoro-2-((4-Methylpiperidin-1-Yl)Sulfonyl)Phenyl)Boronic Acid
CAS No.	1704067-52-6
Molecular Formula	C12H16BF2NO4S
Molecular Weight	319.14 g/mol
Synonyms	[4,5-Difluoro-2-[(4-methyl-1-piperidinyl)sulfonyl]phenyl]boronic acid; 2-((4-Methylpiperidin-1-yl)sulfonyl)-4,5-difluorophenylboronic acid; B-[4,5-Difluoro-2-[(4-methyl-1-piperidinyl)sulfonyl]phenyl]boronic acid; 4,5-Difluoro-2-((4-methylpiperidin-1-yl)sulfonyl)benzeneboronic acid; 1-(Borono-4,5-difluoro-2-sulfonylphenyl)-4-methylpiperidine; CAS 1704067-52-6; PINAP-Boronic Acid Derivative (contextual)
EINECS	Contact for details

Quality Control

Our (4,5-Difluoro-2-((4-Methylpiperidin-1-Yl)Sulfonyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing results from NMR, HPLC, and mass spectrometry are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) when possible to maintain stability. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.