Description

(3,4-Difluoro-5-(Pyrrolidin-1-Yl)Phenyl)Boronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both electron-donating pyrrolidine and electron-withdrawing fluorine substituents, makes it an essential reagent for constructing complex molecular architectures. This compound is primarily utilized by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and CNS-targeted therapeutic research.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection products, leveraging its fluorine atoms for enhanced metabolic stability and bioavailability.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and organic semiconductors, where its specific electronic properties are advantageous.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for target identification and validation studies.
• Catalyst Ligand Development: Serves as a starting material for synthesizing novel bidentate ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	(3,4-Difluoro-5-(Pyrrolidin-1-Yl)Phenyl)Boronic Acid
CAS No.	1704067-48-0
Molecular Formula	C10H12BF2NO2
Molecular Weight	226.02 g/mol
Synonyms	3,4-Difluoro-5-(pyrrolidin-1-yl)benzeneboronic acid; 5-(Pyrrolidin-1-yl)-3,4-difluorophenylboronic acid; (3,4-Difluoro-5-pyrrolidin-1-ylphenyl)boronic acid; B-[3,4-Difluoro-5-(1-pyrrolidinyl)phenyl]boronic acid; 1704067-48-0; AKOS026712293; 1-Pyrrolidine, 1-(4,5-difluoro-3-boronophenyl)-; 3,4-Difluoro-5-(N-pyrrolidinyl)phenylboronic acid
EINECS	Contact for details

Quality Control

Our (3,4-Difluoro-5-(Pyrrolidin-1-Yl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements for advanced research and process chemistry. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.